FINE-NEEDLE ASPIRATION AS THE INITIAL DIAGNOSTIC MODALITY IN MALIGNANT LUNG-DISEASE

Cytologic detection of lung cancer is accepted, accurate, and time-hon ored. Typically, cytologic workup of a radiologic abnormality proceeds sequentially from sputum to bronchoalveolar cytology, and, if necessa ry, to fine-needle aspiration biopsy (FNA). Initial use of FNA in lung cancer diagnosis is controversial, but increasingly popular. We there fore decided to objectively assess current practice in cytologic lung cancer diagnosis at our institution. All pulmonary cytologic diagnoses for 1993 and the first half of 1994 were retrieved. Positive diagnose s were then used to access all patient data. Patients were stratified according to the specimen from which the first positive diagnosis was obtained. Of 542 pulmonary cytology specimens, 15% were sputa, 65% wer e bronchoalveolar, and 20% were FNAs. One hundred sixty-one of 172 mal ignant diagnoses were first diagnoses. Three percent of first malignan t diagnoses were made from sputa, 47% were from lavages, and 50% were from FNAs. Although FNAs comprised just 20% of all pulmonary cytologie s, 50% of all new malignant cytologic diagnoses were made by FNA. Init ial use of FNA is successful, has a high diagnostic yield and low comp lication rate, and offers the most direct approach to diagnosis. (C) 1 996 Wiley-Liss, Inc.