AMITRAZ EFFECTS ON FOOT-AND-MOUTH-DISEASE VIRUS IN MAMMALIAN-CELLS IN-VITRO

The toxicity of the acaricide amitraz and its effect on foot-and-mouth disease virus multiplication were evaluated in IB-RS-2 cells in vitro . A reduction of cell growth rate that was dependent on the dose and t he length of treatment was observed in cells exposed to amitraz concen trations ranging from 20 to 50 mu g/ml. Foot-and-mouth disease virus i nfectivity remained essentially unchanged in cells exposed to amitraz (20 mu g/ml) 24 hr prior to virus infection or after the adsorption pe riod. Viral RNA synthesis evaluated through [H-3]uridine incorporation in cells treated for 24 hr prior to infection was not affected by ami traz. (C) 1996 Academic Press, Inc.