THE SEQUENCE OF 12.8 KB FROM THE LEFT ARM OF CHROMOSOME XIV REVEALS ASIGMA-ELEMENT, A PRO-TRANSFER-RNA AND 6 COMPLETE OPEN READING FRAMES,ONE OF WHICH ENCODES A PROTEIN SIMILAR TO THE HUMAN LEUKOTRIENE A(4) HYDROLASE

We have determined the nucleotide sequence of a 12.8 kb fragment from the left arm of chromosome XIV carried by the cosmid 14-16d. An analys is of the sequence reveals the presence of a sigma element, a pro-tRNA gene and eight open reading frames, six of which are complete. All of the eight open reading frames correspond to new genes. Of the eight n ew genes, two show strong similarities to a pair of new genes from chr omosome IX, suggesting an ancestral duplication, and one gene encodes a protein similar to mammalian leukotriene A(4) hydrolase. The sequenc e has been deposited in the EMBL data bank under the Accession Number X94547.