THE INFLUENCE OF PEFLOXACINE ON EXPERIMENTAL ADRIAMYCIN-INDUCED NEPHROTIC SYNDROME IN RATS

Initial reports on antiproteinuric effect of pefloxacine in small grou ps of patients with minimal-change nephropathy (MCN) and focal and seg mental glomerulosclerosis (FSGS) have not been confirmed in other pape rs. To assess its antiproteinuric effect in experimental animals we ad ministered pefloxacine to rats with adriamycin nephropathy showing mor phological changes resembling human minimal-change disease or focal se gmental glomerulosclerosis, and clinically with full-blown nephrotic s yndrome. Pefloxacine treatment was at least partially effective in pre venting further increase of proteinuria in rats with adriamycin nephro pathy. The mechanism of this effect remains unclear and deserves furth er studies concentrating on the glomerular cytokine network and glomer ular production of reactive oxygen species.