ERYTHROCYTE NUCLEOTIDES AND BLOOD HYPOXANTHINE IN PATIENTS WITH UREMIA EVALUATED IMMEDIATELY AND 24 HOURS AFTER HEMODIALYSIS

Using high-performance liquid chromatography, concentrations of erythr ocyte adenine nucleotides and hypoxanthine were evaluated in patients undergoing regular acetate hemodialysis before dialysis, immediately f ollowing dialysis, and 24 hr after It was shown that adenosine triphos phate concentration was maintained consistently high, not only just af ter hemodialysis but also 24 hr later There was also no difference in concentration of mono- and diphosphates of adenosine. Hypoxanthine con centration decreased twofold after hemodialysis. However it was still markedly higher than normal values. The level of hypoxanthine was main tained at the postdialysis level, 24 hr later This suggests that hypox anthine production could be stimulated during acetate dialysis.