We report the use of continuous venovenous hemodiafiltration (CVVHD) i
n a case of massive intentional ingestion of pentobarbital associated
with severe coma and hypotension. Despite a poor hemodynamic state, to
xic epuration (15% of drug ingested) was obtained. However death occur
red 7 hr after the end of treatment. This report suggests that CVVHD c
an be effective in the treatment of massive pentobarbital intoxication
.