SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME BISQUINOLONES

Authors
COPPEL RL DEADY LW LORIA PM OLDEN DC TURNIDGE JD
Citation
Rl. Coppel et al., SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME BISQUINOLONES, Australian Journal of Chemistry, 49(2), 1996, pp. 255-259
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Australian Journal of Chemistry → ACNP
ISSN journal
00049425
Volume
49
Issue
2
Year of publication
1996
Pages
255 - 259
Database
ISI
SICI code
0004-9425(1996)49:2<255:SAAAOS>2.0.ZU;2-1
Abstract
Ten 'bisquinolones' were prepared by joining two molecules of norfloxa cin, or 1,8-naphthyridine and benzo[c][1,8]naphthyridine derivatives, with various aliphatic linkers. These were tested against 17 bacteria strains but none showed more than slight activity (MIC greater than or equal to 10 mg/l). However, a 'monoquinolone' derived from benzo[c][1 ,8]naphthyridine showed greater activity than norfloxacin against a st rain of Acinetobacter.