Background: Weaning from the mechanical ventilator often proves to be
difficult after prolonged ventilation due to excessive load or decreas
ed capacity of the respiratory muscles. In the present retrospective s
tudy we examined the impact of the nocturnal mechanical ventilation du
ring the ''post-weaning-period'' of long-term ventilated patients. Pat
ients and Methods: We studied 43 patients (23 men, 59.1 +/- 14.6 years
) with chronic respiratory failure who were transmitted from external
ICUs alter a mechanical ventilation period of 57.5 +/- 60.3 days. The
weaning regime consisted of an individually adapted volume-cycled vent
ilation. Ii the patients were hypercapnic (pCO(2) > 48 mm Hg) alter th
e first 24-hour-period of spontaneous breathing without supplemental o
xygen nocturnal mechanical ventilation was initiated. Results and Conc
lusions: In a retrospective study we could show that the derision to i
nitiate invasive or noninvasive nocturnal mechanical ventilation after
successful weaning primarily depends on the question whether a chroni
c hypercapnic respiratory failure persisted also alter weaning from lo
ng-term mechanical ventilation. In about 40%, of unselected patients n
octurnal mechanical ventilation stabilized the weaning success whereas
60% of the patients did not need any further nocturnal mechanical ven
tilation.