FUNCTIONAL-ACTIVITY OF PERIPHERAL PHAGOCY TES IN HIV-INFECTED PERSONSAND PATIENTS WITH RECURRENT HERPES-SIMPLEX VIRAL-INFECTION

The functional activity of peripheral phagocytes were comparatively st udied in 14 HIV-infected patients and 28 patients with chronic Herpes simplex viral infection. The two groups exhibited lowered adhesive cap acity of phagocytes, impaired production and excretion of active oxyge n metabolites. In addition, the patients with chronic Herpes simplex i nfection showed much elevated levels of myeloperoxidase and acid phosp hatase, which indicated its compensatory pattern. The HIV infected had no enhanced enzymatic activity. One cannot rule out that these differ ences in the functional activity of phagocytes are associated with dif ferent effects of viral peptides on the cellular wall of phagocytes.