DIRECTLY REPEATED INSERTION OF 9-NUCLEOTIDE SEQUENCE DETECTED IN PENICILLIN-BINDING PROTEIN 2B GENE OF PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE

Authors
YAMANE A NAKANO H ASAHI Y UBUKATA K KONNO M
Citation
A. Yamane et al., DIRECTLY REPEATED INSERTION OF 9-NUCLEOTIDE SEQUENCE DETECTED IN PENICILLIN-BINDING PROTEIN 2B GENE OF PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE, Antimicrobial agents and chemotherapy, 40(5), 1996, pp. 1257-1259
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
5
Year of publication
1996
Pages
1257 - 1259
Database
ISI
SICI code
0066-4804(1996)40:5<1257:DRIO9S>2.0.ZU;2-1
Abstract
We investigated the molecular mechanism of 50 penicillin-resistant Str eptococcus pneumoniae strains (penicillin: MIC, greater than or equal to 0.125 mu g/ml) having neither class A nor class B mutations in the penicillin-binding protein 2B gene (pbp2b). An analysis of the nucleot ide sequences of the pbp2b genes from seven strains revealed an unique direct repeat of 9 nucleotides (TGGTATACT) between active-site serine (residue 385) and Ser-X-Asn (residues 442 to 444) motifs. The same in sertion was detected in 13 strains.