IN-VITRO ACTIVITIES OF SEMISYNTHETIC PNEUMOCANDIN L-733,560 AGAINST FLUCONAZOLE-RESISTANT AND FLUCONAZOLE-SUSCEPTIBLE CANDIDA-ALBICANS ISOLATES

Lipopeptide L-733,560 is a water-soluble derivative of pneumocandin B- 0 that exhibits enhanced anti-Candida activity. We investigated the in vitro activity of L-733,560 compared with those of amphotericin B, fl ucytosine, and itraconazole, against fluconazole-resistant (n = 44) an d fluconazole-susceptible (n = 46) Candida albicans isolates. Tests we re performed with a photometer-read broth microdilution method with RP MI-2% glucose and National Committee for Clinical Laboratory Standards reference strains. Except for those of itraconazole, MICs were not si gnificantly different between the two groups of isolates, as expected for agents with different mechanisms of action. L-733,560 was the most active agent against C. albicans, with MICs for 50 and 90% of the str ains tested of 0.01 and 0.06 mu g/ml, respectively.