TROPHOZOITE ELIMINATION IN A RAT MODEL OF PNEUMOCYSTIS-CARINII PNEUMONIA BY CLINICALLY ACHIEVABLE PLASMA DEFEROXAMINE CONCENTRATIONS

Authors
MERALI S CHIN K GRADY RW CLARKSON AB
Citation
S. Merali et al., TROPHOZOITE ELIMINATION IN A RAT MODEL OF PNEUMOCYSTIS-CARINII PNEUMONIA BY CLINICALLY ACHIEVABLE PLASMA DEFEROXAMINE CONCENTRATIONS, Antimicrobial agents and chemotherapy, 40(5), 1996, pp. 1298-1300
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
5
Year of publication
1996
Pages
1298 - 1300
Database
ISI
SICI code
0066-4804(1996)40:5<1298:TEIARM>2.0.ZU;2-G
Abstract
In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of greater than or eq ual to 1.5 mu g ml(-1) eliminated the trophozoite life cycle stage. Si nce this concentration is well below that routinely achieved in patien ts treated for iron overload, deferoxamine has promise as a therapy fo r AIDS-associated P. carinii pneumonia.