TREATMENT OF STAPHYLOCOCCUS-AUREUS CATHETER-RELATED INFECTION AND INFECTIVE ENDOCARDITIS WITH GRANULOCYTE-COLONY-STIMULATING FACTOR IN THE EXPERIMENTAL RABBIT MODEL

Citation
U. Frank et Hf. Chambers, TREATMENT OF STAPHYLOCOCCUS-AUREUS CATHETER-RELATED INFECTION AND INFECTIVE ENDOCARDITIS WITH GRANULOCYTE-COLONY-STIMULATING FACTOR IN THE EXPERIMENTAL RABBIT MODEL, Antimicrobial agents and chemotherapy, 40(5), 1996, pp. 1308-1310
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
ISSN journal
00664804
Volume
40
Issue
5
Year of publication
1996
Pages
1308 - 1310
Database
ISI
SICI code
0066-4804(1996)40:5<1308:TOSCIA>2.0.ZU;2-4
Abstract
The role of granulocyte colony-stimulating factor with and without ant ibiotics in the treatment of catheter-related infection and infective endocarditis caused by methicillin-susceptible Staphylococcus aureus w as assessed in the experimental rabbit model. Granulocyte colony-stimu lating factor stimulated leukocytosis in infected animals but did not increase the clearance of methicillin-susceptible S. aureus from perip heral blood, subcutaneous port catheters, intravascular cardiac cathet ers, or aortic valve vegetations.