CONCENTRATIONS OF CEFTRIAXONE (1,000 MILLIGRAMS INTRAVENOUSLY) IN ABDOMINAL TISSUES DURING OPEN PROSTATECTOMY

Ceftriaxone concentrations in abdominal tissues were evaluated at diff erent stages of open prostatectomy. Ceftriaxone was administered as an tibiotic prophylaxis, and 15 consecutive patients were given a single dose of ceftriaxone (1,000 mg intravenously in 1 min) 30 min before su rgery. Ceftriaxone concentrations in tissue were determined at three s tages of the surgical procedure: upon the opening of the abdominal cav ity, during the prostatectomy, and upon the closure of the abdominal c avity. Samples of the following tissues or sample were assayed: epiplo ic and abdominal-wall fat; Retzius' space, bladder, and prostate tissu e; and urine, During the different stages of the surgical procedure, f or all patients, and in the different tested tissues, ceftriaxone conc entrations greater than or equal to the cutoff point (4 mu g/g of tiss ue) were measured. The highest concentrations were obtained in the bla dder (43 +/- 18 mu g/g) and in the prostate (35 +/- 18 mu g/g). In fat ty tissues, concentrations were between 13 +/- 5 and 22 +/- 8 mu g/g. All patients (15 of 15) had ceftriaxone levels in tissue greater than the MICs for the potential pathogens (Staphylococcus aureus, Escherich ia coli, Klebsiella pneumoniae, and Proteus mirabilis). In conclusion, during open prostatectomy and after the use of a single dose of ceftr iaxone (1,000 mg), high antibiotic levels were obtained throughout the surgical procedure in the tissues potentially involved in postoperati ve infection.