KILL KINETICS AND REGROWTH PATTERNS OF PSEUDOMONAS-AERUGINOSA EXPOSEDTO CONCENTRATION-TIME PROFILES OF TOBRAMYCIN SIMULATING IN-VIVO INFUSION AND BOLUS DOSING

Authors
WOOD PJ IOANNIDESDEMOS LL BASTONE EB SPICER WJ MCLEAN AJ
Citation
Pj. Wood et al., KILL KINETICS AND REGROWTH PATTERNS OF PSEUDOMONAS-AERUGINOSA EXPOSEDTO CONCENTRATION-TIME PROFILES OF TOBRAMYCIN SIMULATING IN-VIVO INFUSION AND BOLUS DOSING, Antimicrobial agents and chemotherapy, 40(5), 1996, pp. 1321-1324
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
5
Year of publication
1996
Pages
1321 - 1324
Database
ISI
SICI code
0066-4804(1996)40:5<1321:KKARPO>2.0.ZU;2-O
Abstract
Pseudomonas aeruginosa ATCC 27853 was exposed to tobramycin concentrat ion-time profiles modelling in vivo bolus and infusion dosing, Depende nce of bactericidal and bacteriostatic activity on the initial profile of peak concentration (bolus effect > infusion) and area under the an tibiotic concentration-time curve was observed at peak concentration/M IC ratios of 10 or below.