PROSTAGLANDIN-METABOLIZING ENZYMES DURING PREGNANCY - CHARACTERIZATION OF NAD(-DEPENDENT PROSTAGLANDIN DEHYDROGENASE, CARBONYL REDUCTASE, AND CYTOCHROME P450-DEPENDENT PROSTAGLANDIN OMEGA-HYDROXYLASE())

Authors
OKITA RT OKITA JR
Citation
Rt. Okita et Jr. Okita, PROSTAGLANDIN-METABOLIZING ENZYMES DURING PREGNANCY - CHARACTERIZATION OF NAD(-DEPENDENT PROSTAGLANDIN DEHYDROGENASE, CARBONYL REDUCTASE, AND CYTOCHROME P450-DEPENDENT PROSTAGLANDIN OMEGA-HYDROXYLASE()), Critical reviews in biochemistry and molecular biology, 31(2), 1996, pp. 101-126
Citations number
123
Categorie Soggetti
Biology
Journal title
Critical reviews in biochemistry and molecular biology → ACNP
ISSN journal
10409238
Volume
31
Issue
2
Year of publication
1996
Pages
101 - 126
Database
ISI
SICI code
1040-9238(1996)31:2<101:PEDP-C>2.0.ZU;2-E
Abstract
Prostaglandins E(2) and F-2 alpha regulate a number of physiological f unctions in reproductive tissues, and concentrations of these bioactiv e modulators increase during pregnancy. Corresponding to the increase in circulating levels of prostaglandins during pregnancy is an increas e in enzymes that metabolize these agents. Three prostaglandin-metabol izing enzymes induced during pregnancy are NAD(+)-dependent 15-hydroxy prostaglandin dehydrogenase (PGDH), NADPH-dependent carbonyl reductase , and cytochrome P450-dependent prostaglandin omega- or 20-hydroxylase . This review discusses the biochemical properties, regulation, and po ssible functions of these three enzymes.