VITAMIN-C SPRAY-DRYING - STUDY OF THE THERMAL CONSTRAINT

Temperature variation in the spray drying method has no effect on the ascorbic acid molecule. No chemical interaction between the colloidal silica and the ascorbic acid could be determined, but a physicochemica l interaction ''absorption'' was determined. Colloidal silica improved the final yield of spray drying in proportion To its concentration. N o polymorphic forms could be determined in the spray-dried ascorbic ac id. Drug release from the ascorbic acid spray dried was found to be de pendent on the Aerosil content: highest release rates were obtained wi th Aerosil.