DRUG-RELEASE FROM SPHERICAL-PARTICLES UNDER NONSINK CONDITIONS .1. THEORETICAL EVALUATION

Authors
ABUKHALAF AM SOLIMAN MA
Citation
Am. Abukhalaf et Ma. Soliman, DRUG-RELEASE FROM SPHERICAL-PARTICLES UNDER NONSINK CONDITIONS .1. THEORETICAL EVALUATION, Drug development and industrial pharmacy, 22(5), 1996, pp. 465-469
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
22
Issue
5
Year of publication
1996
Pages
465 - 469
Database
ISI
SICI code
0363-9045(1996)22:5<465:DFSUNC>2.0.ZU;2-0
Abstract
Mathematical models have been developed to describe the release rate o f drugs from spherical particles under nonsink conditions. Full and ap proximate analytical solutions have been derived for cases of solid-ph ase resistance only, for an additional interfacial resistance, and for membrane resistance only. These solutions provide a simple means for the determination of release characteristics of drugs from different t ypes of formulations. It is shown that the perfect sink model is a spe cial case of these nonsink models.