CHARACTERIZATION OF NITROSATION PRODUCTS IN COSMETICS RAW-MATERIALS BY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY TECHNIQUES

Characterization of nitrosation products in cosmetics raw material sam ples has been accomplished by three liquid chromatography/mass spectro metry (LC/MS) techniques, Two of the techniques involved conventional methodologies of LC/MS and LC/tandem mass spectrometry, both of which can be used to detect and identify products formed under extreme-nitro sation conditions, The third technique utilized an on-line coupling of a photolysis reactor with the LC/MS, and it may be used as a rapid an d specific means of screening for the presence of known and unknown N- nitrosamines, which may be carcinogenic.