LACK OF RELATIONSHIP BETWEEN SYSTEMIC EXPOSURE FOR THE COMPONENT DRUGS OF THE FLUOROURACIL, EPIRUBICIN, AND 4-HYDROXYCYCLOPHOSPHAMIDE REGIMEN IN BREAST-CANCER PATIENTS
M. Sandstrom et al., LACK OF RELATIONSHIP BETWEEN SYSTEMIC EXPOSURE FOR THE COMPONENT DRUGS OF THE FLUOROURACIL, EPIRUBICIN, AND 4-HYDROXYCYCLOPHOSPHAMIDE REGIMEN IN BREAST-CANCER PATIENTS, Journal of clinical oncology, 14(5), 1996, pp. 1581-1588
Purpose: The aim of this study was to investigate the covariance betwe
en the pharmacokinetics of the three components of the FEC regimen, ep
irubicin (EPI), fluorouracil (5-FU), and the cyclophosphamide (CP) met
abolite 4-hydroxycyclophosphamide (4-OHCP), in breast cancer patients.
Patients and Methods: Data from 21 women were collected over ct total
of 35 cycles, 5-FU (300 to 600 mg/m(2)) and CP (300 to 600 mg/m(2)) w
ere administered as bolus injections, whereas EPI (15 to 60 mg/m(2)) w
as administered either as a bolus injection or as an infusion, The pha
rmacokinetics of the component drugs were monitored using a limited sa
mpling scheme, Population pharmacokinetic models for each of the three
drugs were developed using the program NONMEM. Results: The data for
5-FU were best described by a one-compartment model with nonlinear eli
mination, where the maximal rate of elimination (Vmax) and the concent
ration at which the elimination was half-maximal (Km) were 105 mg/L .
h and 27 mg/L, respectively. EPI concentration-time profiles showed a
triexponential decline, with a mean terminal half-life of 24 hours and
a clearance (CL) of 59 L/h. The elimination of 4-OHCP was monoexponen
tial, with a mean half-life of 7 hours. The interindividual coefficien
ts of variation (CVs) in CL were 30%, 22%, and 41% for 5-FU, EPI, and
4-OHCP, respectively. The corresponding values for intrapatient course
-to-course variability in CL were 11%, 8%, and 27%. No significant cor
relation in any of the pharmacokinetic parameters between the drugs wa
s found. Conclusion: Individualization of dosing of the FEC regimen us
ing therapeutic drug monitoring and attempts to find concentration-res
ponse relationships may be successful, but requires that the exposure
of all three drugs is considered simultaneously (C) 1996 by American S
ociety of Clinical Oncology.