CHARACTERIZATION OF A DE-NOVO T(Y-9)(Q11.2-Q22) BY FISH TECHNIQUE

A new case with a de novo translocation involving the long arms of chr omosomes Y and 9 i.e. 46, X, t(Y;9) (q11.2;q22) was noted in a phenoty pically normal male as revealed by GTG technique and subsequently conf irmed using dual color whole chromosome painting probes, Since the Yq1 1.2 region was involved in the translocation the fecundity status of t he individual has been questioned. Previous cases with (Y;autosomal) t ranslocations have produced males with azoospermia, a variety of male gamete deformities and idiopathic sterility, The azoospermic factor (A ZF) on the distal Yq11 band, which apparently controls spermatogenesis , may have been adversely affected due to a microdeletion, rearrangeme nt or complete loss as a result of the translocation mechanism, Testic ular histological and fertility tests of the proband at a postpubescen t age will reveal the status, The sex determining region (SRY) on the Yp, which has been equated with the testis determining factor (TDF), i s believed to be intact, Dual color whole chromosome painting probes, which served as an important adjunct to GTG banding, increased the deg ree of certainty for the characterization of the involved translocatio n. A concise review of balanced (Y; autosome) translocation cases are annotated here.