Ha. Lekan et al., SPROUTING OF A-BETA FIBERS INTO LAMINA-II OF THE RAT DORSAL HORN IN PERIPHERAL NEUROPATHY, Neuroscience letters, 208(3), 1996, pp. 147-150
Cholera toxin beta-subunit conjugated to horseradish peroxidase was us
ed to label the large myelinated (A beta) fiber input to the dorsal ho
rn in a model of peripheral neuropathy induced by tight ligation of th
e L5 and L6 spinal nerves. Following induction of neuropathy, A beta f
ibers were present in lamina II of the ipsilateral dorsal horn, a regi
on normally devoid of A beta input. This reorganization of large fiber
input to the superficial dorsal horn provides some anatomical basis f
or sensory changes found in this model of neuropathic pain.