ENANTIOSELECTIVE HYDROGENATION OF DEHYDROAMINO ACID-DERIVATIVES USINGPINDOPHOS-RHODIUM AS CHIRAL CATALYST

Citation
Hj. Kreuzfeld et al., ENANTIOSELECTIVE HYDROGENATION OF DEHYDROAMINO ACID-DERIVATIVES USINGPINDOPHOS-RHODIUM AS CHIRAL CATALYST, Tetrahedron : asymmetry, 7(4), 1996, pp. 1011-1018
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
ISSN journal
09574166
Volume
7
Issue
4
Year of publication
1996
Pages
1011 - 1018
Database
ISI
SICI code
0957-4166(1996)7:4<1011:EHODAU>2.0.ZU;2-I
Abstract
The enantiomers of PINDOPHOS, the aminophosphine phosphinite derivativ e of the commercial beta-blocker Pindolol, were prepared and used as l igands in the rhodium catalyzed asymmetric hydrogenation of non-protei nogenic amino acid precursors. The isolated (R)- and (S)-configured rh odium complexes are highly active catalysts leading to (L)- or (D)-ami no acids. Enantiomeric excesses between 92 and 95% ee could be realize d. The newly obtained amino acid derivatives were fully characterized by NMR spectroscopy. Copyright (C) 1996 Elsevier Science Ltd