Hj. Kreuzfeld et al., ENANTIOSELECTIVE HYDROGENATION OF DEHYDROAMINO ACID-DERIVATIVES USINGPINDOPHOS-RHODIUM AS CHIRAL CATALYST, Tetrahedron : asymmetry, 7(4), 1996, pp. 1011-1018
The enantiomers of PINDOPHOS, the aminophosphine phosphinite derivativ
e of the commercial beta-blocker Pindolol, were prepared and used as l
igands in the rhodium catalyzed asymmetric hydrogenation of non-protei
nogenic amino acid precursors. The isolated (R)- and (S)-configured rh
odium complexes are highly active catalysts leading to (L)- or (D)-ami
no acids. Enantiomeric excesses between 92 and 95% ee could be realize
d. The newly obtained amino acid derivatives were fully characterized
by NMR spectroscopy. Copyright (C) 1996 Elsevier Science Ltd