ENANTIOSELECTIVE SYNTHESES AND RESOLUTION OF THE KEY WHITE INTERMEDIATE FOR THE SYNTHESIS OF TRISPORIC ACIDS

Authors
BACIGALUPPO JA COLOMBO MI PREITE MD ZINCZUK J RUVEDA EA SIELER J
Citation
Ja. Bacigaluppo et al., ENANTIOSELECTIVE SYNTHESES AND RESOLUTION OF THE KEY WHITE INTERMEDIATE FOR THE SYNTHESIS OF TRISPORIC ACIDS, Tetrahedron : asymmetry, 7(4), 1996, pp. 1041-1057
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
4
Year of publication
1996
Pages
1041 - 1057
Database
ISI
SICI code
0957-4166(1996)7:4<1041:ESAROT>2.0.ZU;2-B
Abstract
Two asymmetric syntheses of the alkylated cyclohexenone carboxylic aci d moiety, the key White intermediate (4a), of trisporic acids A, B and C are described. The syntheses feature a Michael addition in tandem w ith an aldol condensation as the central step. The resolution of this readily available intermediate is also described. Copyright (C) 1996 E lsevier Science