ABNORMAL MODULATION OF CHOLINERGIC NEUROTRANSMISSION BY OPIOID IN HYPERRESPONSIVE BRONCHUS OF RATS

Authors
MISAWA M SATO J FURUKAWA Y CHIBA Y HOSOKAWA T
Citation
M. Misawa et al., ABNORMAL MODULATION OF CHOLINERGIC NEUROTRANSMISSION BY OPIOID IN HYPERRESPONSIVE BRONCHUS OF RATS, General pharmacology, 27(3), 1996, pp. 441-444
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
27
Issue
3
Year of publication
1996
Pages
441 - 444
Database
ISI
SICI code
0306-3623(1996)27:3<441:AMOCNB>2.0.ZU;2-U
Abstract
1. The electrical field stimulation (EFS) induced bronchoconstriction in vitro in rats challenged by DNP-Ascaris antigen was significantly g reater than that in normal rats. 2. Morphine inhibited the EFS induced bronchoconstriction in normal rats. Whereas the inhibition of EFS ind uced bronchoconstriction by the opioid was little, if any, in the DNP Ascaris challenged rats. 3. These findings suggest that dysfunction of presynaptic inhibitory modulation through the opioid receptor may tak e place in the airways of DNP Ascaris challenged rats.