MODE OF ANTIBACTERIAL ACTION OF TOTAROL, A DITERPENE FROM PODOCARPUS-NAGI

Authors
HARAGUCHI H OIKE S MUROI H KUBO I
Citation
H. Haraguchi et al., MODE OF ANTIBACTERIAL ACTION OF TOTAROL, A DITERPENE FROM PODOCARPUS-NAGI, Planta medica, 62(2), 1996, pp. 122-125
Citations number
50
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
62
Issue
2
Year of publication
1996
Pages
122 - 125
Database
ISI
SICI code
0032-0943(1996)62:2<122:MOAAOT>2.0.ZU;2-Y
Abstract
The antimicrobial mechanism of totarol was studied using Pseudomonas a eruginosa IFO 3080. This diterpene inhibited oxygen consumption and re spiratory-driven proton translocation in whole cells, and oxidation of NADH in membrane preparation. NADH-cytochrome c reductase was inhibit ed by totarol while cytochrome c oxidase was not. NADH-DPIP reductase and NADH-CoQ reductase were also inhibited. The site of respiratory in hibition of totarol was thought to be near CoQ in the bacterial electr on transport chain.