ANTIPLASMODIAL ACTIVITIES AND CYTOTOXIC EFFECTS OF AQUEOUS EXTRACTS AND SESQUITERPENE LACTONES FROM NEUROLAENA-LOBATA

Authors
FRANCOIS G PASSREITER CM WOERDENBAG HJ VANLOOVEREN M
Citation
G. Francois et al., ANTIPLASMODIAL ACTIVITIES AND CYTOTOXIC EFFECTS OF AQUEOUS EXTRACTS AND SESQUITERPENE LACTONES FROM NEUROLAENA-LOBATA, Planta medica, 62(2), 1996, pp. 126-129
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
62
Issue
2
Year of publication
1996
Pages
126 - 129
Database
ISI
SICI code
0032-0943(1996)62:2<126:AAACEO>2.0.ZU;2-T
Abstract
Aqueous and lipophilic extracts of Neurolaena lobata (Asteraceae), obt ained from Guatemala, were tested against Plasmodium falciparum in vit ro. Moreover, sesquiterpene lactones, of the germacranolide and furano heliangolide type, isolated from N. lobata, were shown to be active ag ainst P. falciparum in vitro. In addition to their antiplasmodial acti vity, their cytotoxic effects on human carcinoma cell lines were evalu ated. Structure-activity relationships are discussed.