INDOLOPYRIDOQUINAZOLINE ALKALOIDS WITH ANTIPLATELET AGGREGATION ACTIVITY FROM ZANTHOXYLUM-INTEGRIFOLIOLUM

Authors
SHEEN WS TSAI IL TENG CM KO FN CHEN IS
Citation
Ws. Sheen et al., INDOLOPYRIDOQUINAZOLINE ALKALOIDS WITH ANTIPLATELET AGGREGATION ACTIVITY FROM ZANTHOXYLUM-INTEGRIFOLIOLUM, Planta medica, 62(2), 1996, pp. 175-176
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
62
Issue
2
Year of publication
1996
Pages
175 - 176
Database
ISI
SICI code
0032-0943(1996)62:2<175:IAWAAA>2.0.ZU;2-0
Abstract
Bioassay-guided fractionation led to the isolation of three indolopyri doquinazoline alkaloids, 1-hydroxyrutaecarpine, rutaecarpine, and 1-me thoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylu m integrifoliolum (Rutaceae). 1-Hydroxyrutaecarpine exhibited antiplat elet activity induced by AA and showed an IC50 value of ca. 1-2 mu g/m l.