CONFIRMATION OF 3 SUSCEPTIBILITY GENES TO INSULIN-DEPENDENT DIABETES-MELLITUS - IDDM4, IDDMS AND IDDM8

Previous genome-wide mapping studies have provided suggestive linkage evidence for several novel susceptibility loci responsible for insulin -dependent diabetes mellitus (IDDM); however, the evidence was not suf ficient to confirm the existence of these genes, We analyzed 265 Cauca sian families with IDDM and report the first evidence that meets the s tandard for confirmed linkage for three susceptibility loci, The maxim um LOD scores (MLS) were 3.9, 4.5 and 3.6 in our data set, and 5.0, 4. 6 and 5.0 for our data combined with non-overlapping data from the lit erature, for IDDM4 on chromosome 11q13, IDDM5 on 6q25, and IDDM8 on 6q 27, respectively, However, we could not confirm linkage for IDDM3 on 1 5q26 and IDDM7 on 2q31-q33, or linkage disequilibrium between D2S152 a nd IDDM7.