THE ANTIPLASMID ACTION OF SOME PALLADIUM(II) COMPLEXES OF PHENOTHIAZINE BASED PHARMACEUTICALS AND THE CRYSTAL-STRUCTURE OF PROTONATED DIMETHYLAMINOPROPYL)PHENOTHIAZINE-S]-PALLADIUM(II)

Palladium(II) complexes of phenothiazines were synthesized and examine d for their antiplasmid activity on E. coli. It was found that the com plex of unsubstituted phenothiazine was ineffective; however, the comp lexes of chlorpromazine and promazine were able to eliminate the F'lac plasmid of E. coli and inhibited intercellular plasmid transfer. The crystal structure of [Pd(pzH)Cl-3] (pzH is protonated promazine) has b een determined by X-ray diffraction methods and refined to a residual of 0.028 for 2821 independent observed reflections. The crystals are m onoclinic, space group P2(1)/n; a 8.166(2); b 26.855(5); c 9.141(2) An gstrom; beta 110.65(2)degrees. Promazine is bonded via an S atom to a PdCl3- unit with the charge being balanced by a protonated amino group .