HELIGMOSOMOIDES-POLYGYRUS - RESISTANCE IN INBRED, OUTBRED, AND SELECTED MICE

Mice reared selectively as high- and low-immune responders to reinfect ion with Heligmosomoides polygyrus showed extremes of resistance and s usceptibility after infection when compared to inbred BALB/C, DBA/I, C BA, and SJL/J and outbred Quackenbuah (Q) mice, The levels of anti-H. polygyrus total IgG and IgG1, IgG2b, and IgG3 isotype antibodies detec ted in serum from the seven strains of mice after secondary and the eo sinophil leucocyte counts in blood after both primary and secondary in fections correlated positively and strongly with the levels of protect ive immunity developed when evaluated using a resistance index formula ted from the infectivity, fecundity, and length of adult worms recover ed after infection. (C) 1996 Academic Press, Inc.