Objectives. A large number of studies evaluating adolescent smoking pr
evention programs have been published. Systematic quantitative reviews
of this literature are needed to learn what does and does not work. T
he present meta-analysis focuses on the efficacy of school-based progr
ams. Methods. Evaluations of 94 separate interventions were included i
n the meta-analysis. Studies were screened for methodological rigor an
d those with weaker methodology were segregated from those with more d
efensible methodology; major analyses focused on the latter. Results.
Behavioral effect sizes were found to be largest for interventions wit
h a social reinforcement orientation, moderate for interventions with
either a development or a social norms orientation, and small for inte
rventions with the traditional rational orientation. Attitude effect s
izes followed the same patter, but knowledge effect sizes were similar
across all four orientation categories. Conclusions. Because behavior
al effect represents the fundamental objective of programs for prevent
ion of adolescent tobacco use, the present results indicate that schoo
l-based programs should consider adopting interventions with a social
reinforcement, social norms or developmental orientation.