Molecular sequence data are beginning to provide important insights in
to the evolutionary origin of eukaryotic cells. Global phylogenies of
numerous protein sequences indicate that the eukaryotic cell nucleus i
s a chimera, which has received major contributions from both a Gram-n
egative eubacterium and an archaebacterium. Recent studies also indica
te that the formation of the nuclear envelope and the endoplasmic reti
culum was accompanied by duplication of genes for the molecular chaper
one proteins (e.g. hsp70, hsp90), which facilitate protein transport a
cross membranes. Based on these observations, it is suggested that the
ancestral eukaryotic cell arose by a unique endosymbiotic event invol
ving engulfment of an eocyte archaebacterium by a Gram-negative eubact
erial host.