CHARACTERIZATION OF COMBINATORIAL PEPTIDE LIBRARIES BY ELECTROSPRAY-IONIZATION FOURIER-TRANSFORM MASS-SPECTROMETRY

The advantages of Fourier transform mass spectrometry (FTMS) are preci sion high mass accuracy measurements and the capability of high resolu tion, multistage mass spectrometry together with a number of other adv anced features, These powerful facilities can be used to rapidly scree n complex mixtures without the necessity of chromatographic separation s, The example shown here illustrates the use of the high resolving po wer and accurate mass capabilities of FTMS for the rapid, direct analy sis of a complex mixture, which had been ionized by direct infusion el ectrospray ionization.