Standardized MOD cavities were prepared in 80 human premolars, which w
ere treated with either adhesive resin or copal varnish and then resto
red with amalgam. Fracture resistance of these groups was compared aft
er 24 hours of storage, 4 weeks of storage with thermocycling, and aft
er 500 days of storage. The buccal cusps were loaded at an angle of 30
degrees to the tooth long axis until fracture occurred. Additionally,
survival curves were compared for adhesive resin and copal varnish gr
oups that had been repeatedly load cycled until fracture occurred. The
24-hour adhesive resin group was significantly stronger than the corr
esponding copal varnish group (P < 0.05). However, no significant diff
erences between adhesive resin and copal varnish were found for the ot
her thermocycling, extended 500-day storage, or load cycling tests. In
conclusion, the strengthening effect of an adhesive resin on teeth re
stored with MOD amalgam restorations was transient.