A PRACTICAL ROUTE TO ENANTIOPURE 1,2-AMINOALCOHOLS

Authors
CHANG HT SHARPLESS KB
Citation
Ht. Chang et Kb. Sharpless, A PRACTICAL ROUTE TO ENANTIOPURE 1,2-AMINOALCOHOLS, Tetrahedron letters, 37(19), 1996, pp. 3219-3222
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
19
Year of publication
1996
Pages
3219 - 3222
Database
ISI
SICI code
0040-4039(1996)37:19<3219:APRTE1>2.0.ZU;2-O
Abstract
A series of enantiopure aminoalcohols were synthesized from the corres ponding diols by activation of the diols as cyclic carbonates, azide o pening of the carbonates, and hydrogenation of the resulting azidoalco hols. Factors affecting the azide opening of the carbonates, a simple workup procedure, and a large scale synthesis of (1R,2S)-(-)-2-amino-1 ,2-diphenylethanol are described. (C) 1996 Elsevier Science Ltd.