THE PREPARATION OF ALPHA-SUBSTITUTED, BETA-HYDROXY PIPERIDINES AND PYRROLIDINES - THE TOTAL SYNTHESIS OF FEBRIFUGINE

Authors
BURGESS LE GROSS EKM JURKA J
Citation
Le. Burgess et al., THE PREPARATION OF ALPHA-SUBSTITUTED, BETA-HYDROXY PIPERIDINES AND PYRROLIDINES - THE TOTAL SYNTHESIS OF FEBRIFUGINE, Tetrahedron letters, 37(19), 1996, pp. 3255-3258
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
19
Year of publication
1996
Pages
3255 - 3258
Database
ISI
SICI code
0040-4039(1996)37:19<3255:TPOABP>2.0.ZU;2-P
Abstract
Epoxides generated from cyclic ene carbamates are effective N-acyl imi nium ion precursor and allow for the preparation of beta-hydroxy, alph a-substituted piperidines and pyrrolidines. The total synthesis of rac emic Febrifugine is also described. (C) 1996 Elsevier Science Ltd.