AN EFFICIENT METHOD FOR 4-BETA-ANILINO-4'-DEMETHYLEPIPODOPHYLLOTOXINS- SYNTHESIS OF NPF AND W-68

Citation
A. Kamal et Nl. Gayatri, AN EFFICIENT METHOD FOR 4-BETA-ANILINO-4'-DEMETHYLEPIPODOPHYLLOTOXINS- SYNTHESIS OF NPF AND W-68, Tetrahedron letters, 37(19), 1996, pp. 3359-3362
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404039
Volume
37
Issue
19
Year of publication
1996
Pages
3359 - 3362
Database
ISI
SICI code
0040-4039(1996)37:19<3359:AEMF4>2.0.ZU;2-E
Abstract
4 beta-Substituted podophyllotoxin congeners have been obtained with s ignificant stereoselectivity and improved yields by employing Bu(4)N()I(-) in the displacement reaction of the 4-bromoepipodophyllotoxin. T he DNA topoisomerase II inhibitors, NPF and W-68 have been prepared in good yields by this method. (C) 1996 Published by Elsevier Science Lt d