A. Kamal et Nl. Gayatri, AN EFFICIENT METHOD FOR 4-BETA-ANILINO-4'-DEMETHYLEPIPODOPHYLLOTOXINS- SYNTHESIS OF NPF AND W-68, Tetrahedron letters, 37(19), 1996, pp. 3359-3362
4 beta-Substituted podophyllotoxin congeners have been obtained with s
ignificant stereoselectivity and improved yields by employing Bu(4)N()I(-) in the displacement reaction of the 4-bromoepipodophyllotoxin. T
he DNA topoisomerase II inhibitors, NPF and W-68 have been prepared in
good yields by this method. (C) 1996 Published by Elsevier Science Lt
d