ANTIBODIES TO TAMM-HORSFALL PROTEIN SUBUNITS PREPARED IN-VITRO, IN PATIENTS WITH ACUTE PYELONEPHRITIS

The aim of this study was to determine antibodies to Tamm-Horsfall pro tein subunits in patients with acute pyelonephritis. The protein subun its used in this determination were prepared by chemical treatment of Tamm-Horsfall protein isolated from the urine of healthy individuals. Values for IgG and IgA were significantly higher (p < 0.05 and p < 0.0 1 respectively) in patients than in healthy persons, while IgM class a ntibodies were significantly higher only in the test performed with su bunits obtained with 8.3 mol/l acetic acid (THP-A) (p < 0.05). Values for all three classes determined in the test with THP-A were significa ntly higher in patients with vesicoureteral reflux than in patients wi th normal radiological findings (p < 0.05). Antibodies to Tamm-Horsfal l protein subunits isolated from the urine of patients with acute pyel onephritis should also be determined.