A 25-year-old patient with an acquired ichthyosis-like condition is de
scribed. Histologic and molecular biologic examination of the fine, wh
itish, scaling skin lesions suggested the diagnosis of mycosis fungoid
es. Typical lesions of mycosis fungoides, such as patches, plaques, or
tumors, were not present. To the best of our knowledge, this is the f
irst case of mycosis fungoides presenting solely with the clinical fea
tures of acquired ichthyosis. The sudden appearance of ichthyosiform s
kin changes in adults must be taken seriously and the underlying cause
must be evaluated. A skin biopsy should be performed in all cases of
acquired ichthyosis to rule out mycosis fungoides.