Le. Esperanza et Na. Fenske, HYPERANDROGENISM, INSULIN-RESISTANCE, AND ACANTHOSIS NIGRICANS (HAIR-AN) SYNDROME - SPONTANEOUS REMISSION IN A 15-YEAR-OLD, Journal of the American Academy of Dermatology, 34(5), 1996, pp. 892-897
Acanthosis nigricans is associated with many diseases, including inter
nal malignancies, genetic disorders, and endocrine abnormalities. Insu
lin resistance frequently accompanies endocrine-associated acanthosis
nigricans. We describe a patient with acanthosis nigricans associated
with hyperandrogenism and extreme insulin resistance that spontaneousl
y resolved after a marked decrease in insulin receptor antibodies.