SILENT AFFERENTS - A SEPARATE CLASS OF PRIMARY AFFERENTS

1. In recent years, fine sensory nerve fibres have been detected that are not excited by physiological stimuli, even at potentially tissue d amaging intensities, These silent afferents are known to supply knee j oint, skin and viscera; in the last case, silent afferents seem to be particularly numerous, 2. When an artificial inflammation is induced, many silent afferents develop spike activity, others remain quiescent, Silent afferents that do respond probably have a nociceptive sensory function, Under inflammatory conditions some silent afferents are sens itized to physiological stimuli, others are probably chemospecific. 3. Orthodromic activity in silent afferents may sum spatially and tempor ally in second order neurons with other nociceptive information and ma y thereby contribute to different pain states, Furthermore, there is e vidence that the activation of chemospecific silent afferents may lead to sensitization of nociceptive dorsal horn neurons, 4. Some silent a fferents probably contain neuropeptides that may be liberated under pa thophysiological conditions, such as inflammation, 5. Whether certain pathological states can be exclusively attributed to the activation of silent afferents or whether silent afferents sustain the functions of 'conventional' nociceptors remains to be clarified.