G. Leyendecker et L. Wildt, FROM PHYSIOLOGY TO CLINICS - 20 YEARS OF EXPERIENCE WITH PULSATILE GNRH, European journal of obstetrics, gynecology, and reproductive biology, 65, 1996, pp. 3-12
The physiological and the pathophysiological basis of unvariant pulsat
ile administration of gonadotrophin-releasing hormone (GnRH) as well a
s the clinical results are reviewed. Pulsatile administration of GnRH
not only proved to be a very effective treatment mode but also became
an important tool for research in the central control of pituitary and
ovarian function under normal and disease conditions.