THE ROLE OF THE GNRH DOSE AND THE ROUTE OF ADMINISTRATION ON TREATMENT OUTCOME AND COMPLICATIONS

A literature review is given on the pulsedose, the pulse interval, the route of administration and the complications of pulsatile GnRH thera py in hypogonadotropic patients. It is concluded that the treatment re gimen should be as follows: 1. Start first treatment cycle with a puls edose of 5 mu g/pulse and a pulse interval of 120 min. 2. Regardless t he outcome of the first treatment cycle, during the second cycle eithe r the dose should be increased to 10 mu g/pulse or the interval should be reduced to 60 min. 3. Only if insufficient results are obtained wi th this pulsedose should the dose be increased to a maximum of 20 mu g /pulse. With respect to the route of administration it is concluded th at the choice of the i.v. versus the s.c. route of administration is m ainly one of personal preference. Complications are mainly local infla mmatory reactions. All other side effects and complications are rare a nd of minor importance.