E. Page et al., CARDIAC-OUTPUT RESPONSE TO DYNAMIC EXERCISE AFTER ATRIAL SWITCH REPAIR FOR TRANSPOSITION OF THE GREAT-ARTERIES, The American journal of cardiology, 77(10), 1996, pp. 892
Results from this study showed that patients who underwent successful
operation for transposition of the great arteries had no appropriate i
ncrease in stroke volume in response to exercise of a nature similar t
o common recreational activities. The impairment, most likely due to d
isturbances in both venous return and ventricular systolic function, i
s compensated for by an increase in peripheral oxygen extraction; howe
ver, this increase may not be adequate with maturation or during prolo
nged exercise when cardiovascular constraints are more important.