IS LEAD TOXICOSIS A REFLECTION OF ALTERED FATTY-ACID COMPOSITION OF MEMBRANES

Authors
DONALDSON WE KNOWLES SO
Citation
We. Donaldson et So. Knowles, IS LEAD TOXICOSIS A REFLECTION OF ALTERED FATTY-ACID COMPOSITION OF MEMBRANES, Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology, 104(3), 1993, pp. 377-379
Citations number
41
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology → ACNP
ISSN journal
07428413
Volume
104
Issue
3
Year of publication
1993
Pages
377 - 379
Database
ISI
SICI code
0742-8413(1993)104:3<377:ILTARO>2.0.ZU;2-T
Abstract
1. The premise of this review is that many of the biological effects o f Pb are reflections of tissue peroxidation. 2. Enhanced tissue levels of arachidonic acid in Pb toxicosis appear to be involved in the pero xidative changes. 3. The altered arachidonate metabolism may be relate d to changes in membrane structure and function. 4. The induction of e nhanced glutathione levels in animal tissues by Pb may afford protecti on from peroxidative damage.