INTERFERON TREATMENT FOR CHRONIC HEPATITI S-C IN PATIENTS INFECTED BYTHE HUMAN-IMMUNODEFICIENCY-VIRUS

BACKGROUND: Alfa-interferon (aIFN) is widely recommended for the treat ment of chronic hepatitis C (CHC). Hepatitis C virus (HCV) infection i s very common in injecting drug users (IDUs), which in Spain represent the large number of HIV-infected persons. interaction between human i mmunodeficiency virus (HIV) and HCV in coinfected patients might accel erate the clinical course of HCV-associated liver disease. The efficac y and safety of alFN therapy in HIV-infected patients with CHC is not well known. PATIENTS AND METHODS: In a multicenter, prospective, open, non randomized and partially controlled study, we compared the effica cy and safety of alFN therapy in 119 patients with CHC, of whom 90 wer e HIV-positive and 29 HIV-negative. Interferon was started at 5 mega U tiw for 3 months, followed in responders by 3 megaU tiw for additiona l 9 months. RESULTS: One hundred seven patients completed the study. A normalization of the aminotransferase values at the end of treatment (complete response, CR) was observed in 26/80 (32.5%) HIV-positive and 10/27 (37.0%) HIV-negative individuals (p = 0.666). Relapses at 12 mo nths of stopping alFN were seen in 30.8% of HIV-positive subjects and 12.5% of HIV-negatives (p = 0.403). Side effects were uncommon and did not have severity; only one patient required to stop the medication. However, 3 HIV-positive subjects treated with alFN (3.5% of them) show ed an irreversible fall of CD4+ T-cells below half the baseline values . CONCLUSION: HIV-infected patients with CHC seems to respond to alFN with a similar rate than HIV-negatives. Moreover, the drug is similarl y well tolerated in both groups of patients, although a fall of CD4+ T -cells is an unusual side effect of particular relevance observed in H IV-infected patients.