We report six: cases of insufficiency fractures of the medial femoral
condyle responsible for severe mechanical pain in the medial knee comp
artment in the absence of any identifiable precipitating factor. Sugge
stive changes were seen on initial roentgenograms in only one case, wh
ereas increased radionuclide uptake was a consistent finding on the bo
ne scan. The diagnosis was established only by magnetic resonance imag
ing in five cases. All six patients were women and four were older tha
n 75 years. Two patients had a history of osteoporotic fractures, one
had laboratory test evidence of osteomalacia and one had recurrent ins
ufficiency fractures mistakenly ascribed for several years to migrator
y transient osteoporosis. Bone density was subnormal in five of the si
x patients. Rest and standard analgesics consistently ensured a favora
ble outcome within three to four weeks. To our knowledge there have be
en no previous reports of stress fractures of the medial femoral condy
le. These lesions may be underdiagnosed since they are easily mistaken
for primary osteonecrosis in the absence of magnetic resonance imagin
g. Primary osteonecrosis of the femoral condyle shares several feature
s with insufficiency fractures, including predominance in elderly wome
n with factors responsible for mechanical stress (varum, obesity, triv
ial trauma), mechanical pain, and increased radionuclide uptake. Becau
se some cases of primary osteonecrosis may be secondary to undiagnosed
stress-related microfractures, early diagnosis and elimination of wei
ght bearing are essential.