C-14 LABELING OF A NOVEL ANTIISCHEMIC ADENOSINE A(1) AGONIST AT PURINE C-8

Authors
VALSBORG JS KNUTSEN LJS FOGED C
Citation
Js. Valsborg et al., C-14 LABELING OF A NOVEL ANTIISCHEMIC ADENOSINE A(1) AGONIST AT PURINE C-8, Journal of labelled compounds & radiopharmaceuticals, 38(5), 1996, pp. 497-507
Citations number
13
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
38
Issue
5
Year of publication
1996
Pages
497 - 507
Database
ISI
SICI code
0362-4803(1996)38:5<497:CLOANA>2.0.ZU;2-K
Abstract
A C-14-labelled form of oro-N-[(R)-(2-benzoxazolyl)thio-2-propyl]adeno sine ((1) under bar), a novel antiischaemic adenosine A(1) agonist, ha s been prepared in three steps from C-14]-9-(2,3,5-tri-O-benzoyl-beta- D-ribofuranosyl) -2,6-dichloropurine ((2) under bar). The overall radi ochemical yield was 56%. The radiochemical purity was higher than 98% with a specific radioactivity of 36 mCi/mmol.