Fj. Martinez et al., LUNG-MECHANICS AND DYSPNEA AFTER LUNG TRANSPLANTATION FOR CHRONIC AIR-FLOW OBSTRUCTION, American journal of respiratory and critical care medicine, 153(5), 1996, pp. 1536-1543
Citations number
34
Categorie Soggetti
Emergency Medicine & Critical Care","Respiratory System
Single lung transplantation (SLT) is widely used to treat advanced chr
onic airflow obstruction (CAO). During exercise the native lung should
increase end-expiratory lung volume (EELV) and result in a different
respiratory sensation compared with double lung transplantation (DLT).
Eight SLT recipients and 12 DLT recipients demonstrated a similar max
imal work load and achieved Vover dotO(2) Vover dot(max)/MW was 67.2 /- 4.0% in SLT recipients and 48.5 +/- 3.6% in DLT recipients (p = 0.0
03). All SLT recipients demonstrated an increase in EELV during exerci
se, which was seen in only three of 12 DLT recipients. The change in a
bsolute EELV from rest to peak exercise was different between SLT reci
pients (+0.37 +/- 0.10 L) and DLT recipients (-0.10 +/- 0.06, p = 0.00
02). Tidal flow volume loop analysis demonstrated encroachment of the
expiratory limb in four of seven SLT recipients but in only one of 12
DLT recipients. A lesser peak breathlessness in DLT recipients approac
hed statistical significance (p = 0.051), although the relation of res
piratory sensation versus Vover dotE or Vover dotO(2)% predicted did n
ot differ between the two groups. EELV increases in SLT recipients at
peak exercise, although overall aerobic response is preserved and resp
iratory sensation is similar.